Severe interactionSevereSeparate by 3h
Magnesium glycinate and Fluoroquinolone antibiotic: interaction, severity and spacing
Magnesium glycinate and Fluoroquinolone antibiotic interact because magnesium binds fluoroquinolones in the gut and can reduce absorption by up to 60%, risking treatment failure. Take them 3 hours apart. Severe risk.
Last reviewed: 2026-09-20Reviewed by: StackingRight clinical review
The interaction in detail
| Pair | Magnesium glycinate and Fluoroquinolone antibiotic |
|---|---|
| Type | Nutrient–drug interaction |
| Severity | Severe |
| Required spacing | 3 hours minimum |
| Onset | At the time of dosing |
Mechanism
Magnesium binds fluoroquinolones in the gut and can reduce absorption by up to 60%, risking treatment failure.
What to do
Take the antibiotic at least 2 hours before or 6 hours after magnesium.
How to fit both into one day
Magnesium glycinate
eveningflexible
Magnesium supports parasympathetic tone and muscle relaxation, so evening dosing also helps sleep. Keep it two hours from antibiotics and thyroid medication.
Putting Magnesium glycinate in the evening and Fluoroquinolone antibiotic in the evening satisfies the 3-hour separation without disrupting either one's absorption window.