Magnesium glycinate and ACE inhibitor: interaction, severity and spacing
Magnesium glycinate and ACE inhibitor interact because magnesium supplements can add a small blood-pressure-lowering effect and, at high doses in renal impairment, raise serum magnesium. Take them with care. Mild risk.
The interaction in detail
| Pair | Magnesium glycinate and ACE inhibitor |
|---|---|
| Type | Nutrient–drug interaction |
| Severity | Mild |
| Required spacing | None specified |
| Onset | At the time of dosing |
Mechanism
Magnesium supplements can add a small blood-pressure-lowering effect and, at high doses in renal impairment, raise serum magnesium.
What to do
Typical doses are fine. Discuss with your prescriber if you have reduced kidney function.
How to fit both into one day
Magnesium supports parasympathetic tone and muscle relaxation, so evening dosing also helps sleep. Keep it two hours from antibiotics and thyroid medication.
Take at a consistent time each day. Do not add potassium supplements without checking potassium and kidney function.
Putting Magnesium glycinate in the evening and ACE inhibitor in the morning satisfies the 0-hour separation without disrupting either one's absorption window.