Calcium citrate and ACE inhibitor: interaction, severity and spacing
Calcium citrate and ACE inhibitor interact because calcium supplements may slightly attenuate the blood-pressure effect of ACE inhibitors, though the clinical significance is small. Take them with care. Mild risk.
The interaction in detail
| Pair | Calcium citrate and ACE inhibitor |
|---|---|
| Type | Nutrient–drug interaction |
| Severity | Mild |
| Required spacing | None specified |
| Onset | At the time of dosing |
Mechanism
Calcium supplements may slightly attenuate the blood-pressure effect of ACE inhibitors, though the clinical significance is small.
What to do
No action needed at standard doses; keep calcium consistent.
How to fit both into one day
Calcium absorbs better with food and in doses at or below 500 mg. Take it with vitamin D3, and separate it from iron, zinc and thyroid medication.
Take at a consistent time each day. Do not add potassium supplements without checking potassium and kidney function.
Putting Calcium citrate in the midday and ACE inhibitor in the morning satisfies the 0-hour separation without disrupting either one's absorption window.