Synergy interactionSynergy

Vitamin B6 (P5P) and Magnesium glycinate: interaction, severity and spacing

Vitamin B6 (P5P) and Magnesium glycinate work better together because pyridoxal-5-phosphate increases cellular magnesium retention, so the two work better together than either alone. Take them together rather than separately. This is a synergy, not a conflict.

Last reviewed: 2026-09-20Reviewed by: StackingRight clinical review

The interaction in detail

Summary of the Vitamin B6 (P5P) and Magnesium glycinate interaction
PairVitamin B6 (P5P) and Magnesium glycinate
TypeNutrient interaction
SeveritySynergy
Required spacingNone specified
OnsetAt the time of dosing

Mechanism

Pyridoxal-5-phosphate increases cellular magnesium retention, so the two work better together than either alone.

What to do

Taking B6 with magnesium is well tolerated and may improve magnesium status.

Citationhttps://pubmed.ncbi.nlm.nih.gov/22993754/

Vitamin B6 (P5P) and Magnesium glycinate: common questions