Green tea extract (EGCG) and Statin: interaction, severity and spacing
Green tea extract (EGCG) and Statin interact because high-dose green tea catechins have been reported to inhibit OATP-mediated uptake of statins, modestly raising plasma levels. Take them with care. Mild risk.
The interaction in detail
| Pair | Green tea extract (EGCG) and Statin |
|---|---|
| Type | Nutrient interaction |
| Severity | Mild |
| Required spacing | None specified |
| Onset | At the time of dosing |
Mechanism
High-dose green tea catechins have been reported to inhibit OATP-mediated uptake of statins, modestly raising plasma levels.
What to do
Use a standardised extract at a consistent dose rather than very high intakes.
How to fit both into one day
Take green tea extract with food to reduce the small risk of liver strain, and keep it an hour from any iron dose.
Cholesterol synthesis peaks overnight, so most statins are dosed in the evening. Avoid grapefruit, which raises drug levels.
Putting Green tea extract (EGCG) in the morning and Statin in the evening satisfies the 0-hour separation without disrupting either one's absorption window.