Mild interactionMildSeparate by 2h
Iron bisglycinate and Manganese: interaction, severity and spacing
Iron bisglycinate and Manganese interact because iron and manganese share the DMT1 transporter and can mutually reduce absorption. Take them 2 hours apart. Mild risk.
Last reviewed: 2026-09-20Reviewed by: StackingRight clinical review
The interaction in detail
| Pair | Iron bisglycinate and Manganese |
|---|---|
| Type | Nutrient interaction |
| Severity | Mild |
| Required spacing | 2 hours minimum |
| Onset | At the time of dosing |
Mechanism
Iron and manganese share the DMT1 transporter and can mutually reduce absorption.
What to do
Keep manganese in a multivitamin rather than a standalone high dose, and take it at a different meal from iron.
How to fit both into one day
Iron bisglycinate
morningempty stomach
Non-heme iron absorbs best on an empty stomach with vitamin C. Coffee, tea and calcium can halve absorption, so keep them two hours away.
Putting Iron bisglycinate in the morning and Manganese in the evening satisfies the 2-hour separation without disrupting either one's absorption window.